Associate Scientist, In Vivo Pharmacology (Contract)
Employment Type: Contingent Worker
Reference Number: R264
Associate Scientist In Vivo Pharmacology (Contract Position)
This is what you will do:
You will be working under the supervision of the in vivo Pharmacology Group Leader and will primarily be responsible for generating pre-clinical in vivo data by testing novel small molecule therapies and immunotherapies in clinically relevant mouse cancer models. The role involves supporting primary pharmacology and translational pharmacology programs by identifying and characterizing new cancer therapeutics using various cell lines and genetically engineered in vivo models. This person will determine the optimal doses, routes of administration and dose schedules, prioritize indications, identify biomarkers, elucidate mechanisms of resistance and identify efficacious combinations. The daily activities will include implanting, ear tagging, measuring, and dosing (PO, IP, IV) of various mouse cancer models, collecting tissues, formulating drugs, and providing in vitro and ex vivo support.
You will be responsible for:
Supporting drug discovery projects with relevant in vivo assays and generating primary data packages.
Executing in vivo pharmacology studies in mice (tumor growth inhibition, pharmacodynamic, pharmacokinetic and novel model growth curves).
Use gain-of-function (over expression) and loss-of-function (RNAi, CRISPR/Cas) approaches to study gene function in various in vivo models.
Identifying effective combinations with chemotherapies, targeted therapies or immune-modulatory agents.
Identifying clinically-tractable biomarkers that may guide patient selection or early-stage drug development.
Maintaining vivarium equipment, detailed laboratory files and an electronic notebook.
Presenting in lab meetings to inform and discuss progress, results and future studies.
You will need to have:
A Bachelor’s degree in a science-related field with direct animal research or two-years of
direct animal research experience with no degree required
Experience in rodent handling and procedures, especially in cancer pharmacology
Experience in general laboratory techniques
Highly organized with excellent communication skills
Expertise in Microsoft Office Suite
Must be willing to work off-hours, weekends and holidays at times to support research needs.
The duties of this role are generally conducted in an lab environment. As is typical of a lab-based role, employees must be able, with or without an accommodation to: lift/carry 15/30 pounds unassisted/assisted; work comfortably in a controlled environment with and around biological, infectious, and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.