Executive Leadership

Chuck is the Founder, President and Chief Executive Officer of Mirati Therapeutics, and has been a Board Member since Nov 2012. He was Founder, President and Head of Research and Development at Mirati from 2021 to 2023 and was President, Founder and CEO from Nov 2012 to 2021.

Under his leadership, Mirati has transformed into a precision oncology company focused on advancing drug discovery and research and delivering novel therapeutics that target the genetic drivers of cancer.

Prior to joining Mirati, Chuck was Senior Vice President for Biotherapeutic Clinical Research within Pfizer’s Worldwide Research & Development division. He was at Pfizer from 2003 to 2012, serving in roles of increasing responsibility, including Vice President, Head of Oncology Development and Chief Medical Officer for Pfizer’s Biotherapeutics and Bioinnovation Center. He was responsible for the development of Pfizer’s oncology portfolio, including Inlyta,* Xalkori* and the approval of Sutent.* Prior to Pfizer, Chuck was at Schering-Plough where he was responsible for the Phase I-IV development of several oncology compounds, including Temodar.*

Chuck’s career has also included academic and hospital positions at Stanford and Emory universities. He currently serves on the board of directors at Poseida Therapeutics, PMV Pharma, Acrivon Therapeutics, Odyssey Therapeutics and Terremoto Biosciences. Chuck is also on the Scientific Advisory Board at ALX Oncology. Previously, he served as a member of the board of Array Biopharma from 2014 to 2019 when it was acquired by Pfizer, Inc., Immunomedics from 2019 to 2020 when it was acquired by Gilead, and BCTG Acquisition Corp from 2020 to 2021 when it merged with Tango Therapeutics.

Chuck received his M.D. and Ph.D. degrees from Washington University School of Medicine and completed his post-graduate training at Stanford University. Additionally, he has received research support from the National Institutes of Health and the American Cancer Society, published more than 50 peer-reviewed manuscripts and holds a number of patents and patent applications.

* Trademarks are property of their respective owners.

Jamie joined Mirati in 2013 as Chief Scientific Officer. In his role, Jamie is responsible for drug discovery, translational research, drug manufacturing and companion diagnostics research. At Mirati, Jamie has led activities related to the discovery and advancement of the company’s clinical and preclinical programs, including adagrasib (KRAS G12C selective inhibitor), MRTX1133 (KRAS G12D selective inhibitor) and sitravatinib (spectrum-selective receptor tyrosine kinase (RTK) inhibitor).

Prior to Mirati, Jamie was the head of Oncology Precision Medicine and a member of the executive leadership team in the Oncology Research Unit at Pfizer. He joined Pfizer in 2003, and his responsibilities included leading oncology nonclinical research and translational sciences for programs including Sutent* and Xalkori.*

Prior to Pfizer, Jamie held positions at SUGEN/Pharmacia as a Group Leader on the Preclinical Research and Exploratory Development team. He began his industry experience at Warner Lambert/Parke-Davis.

Jamie currently serves as a member of the board of directors at Boundless Bio and has authored or co-authored over 140 peer-reviewed research articles in scientific journals including Science, Nature, Cancer Cell, Cancer Discovery, New England Journal of Medicine and many others. In addition, he also participates on the editorial boards for Cancer Research and Molecular Cancer Therapeutics and is a member of the Scientific Advisory panel at Bridge Bio/QED.

Jamie received his Ph.D. at North Carolina State University and his B.S. in biology from Northern Illinois University.

* Trademarks are property of their respective owners.

Betsy has served as Chief Accounting Officer and Principal Accounting Officer since September 2023, bringing over 15 years of experience in managing accounting operations and infrastructure, financial reporting and public financing activities. She joined Mirati in June 2020 and has been vice president, finance since July 2021.

Prior to Mirati, Betsy held senior finance and accounting roles at Tocagen, Inc. where she was responsible for managing accounting, financial planning and analysis participating in public financing activities, and key member of the execution of the Company’s reverse merger and Regulus Therapeutics, Inc., where she managed accounting and financial reporting. Previously, Betsy worked in public accounting at Grant Thornton LLP.

Betsy received her Bachelor of Accounting from the University of San Diego. She is a Certified Public Accountant (CPA).

Ben joined Mirati in 2020 as Chief Commercial Officer, bringing with him almost 20 years of industry experience. Ben is responsible for building and leading commercial and medical affairs functions and capabilities as Mirati prepares for commercial readiness. Ben has a long track record of leading commercial teams, including global product launches for innovative oncology treatments. Prior to Mirati, Ben was Senior Vice President, Chief Commercial Officer at Halozyme Therapeutics, where he was responsible for the global commercial strategy for the company’s oncology portfolio.

Prior to Halozyme, Ben spent 17 years at Bristol Myers Squibb in various roles, including General Manager, UK & Ireland, where he oversaw an organization of more than 300 people, and Vice President Marketing, Immuno-Oncology, where he led the commercialization of Yervoy* and oversaw the launch preparedness of Opdivo* across more than eight indications. Ben currently serves as board director at Surface Oncology.

Ben received both his MBA and B.S. in Management from St. John’s University in Queens, New York.

* Trademarks are property of their respective owners.

Peter Lee has served as Chief Compliance Officer of Mirati Therapeutics since 2022, bringing over 16 years of pharmaceutical experience building comprehensive compliance programs for companies including Gilead Sciences, Hyperion Therapeutics and Pharmacyclics.

Prior to Mirati, Peter was Chief Compliance Officer at Provention Bio and Heron Therapeutics. His deep experience includes helping companies prepare for and launch drug and treatment options. Throughout his career, Peter has launched 8 drugs, fostering collaboration within his working teams including Commercial and Medical Affairs functions.

Peter received a Bachelor of Arts from the University of Michigan, He holds a JD from Quinnipiac Law School and received his LLM from Loyola University of Chicago.

John joined Mirati in 2023 as Chief Legal Officer and has more than 25 years of legal and business leadership across leading global biotech companies. Most recently, he was Executive Vice President and Chief Legal Officer at Olema Pharmaceuticals and helped build out the company and lead it through its successful Series C financing and 2020 Initial Public Offering.

Previously he was Executive Vice President and General Counsel for Portola Pharmaceuticals, Inc., where he was responsible for all legal, governance and compliance matters supporting the company’s products, its corporate strategy, and the build-out of its operations in the United States and Europe, which culminated in Portola’s acquisition by Alexion Pharmaceuticals, Inc. in July 2020. Prior to Portola, John was General Counsel of Alexion for more than five years during a period of tremendous growth and value creation. He was responsible for overseeing all global legal matters spanning 50 countries, as well as managing Alexion’s Global Government Affairs and Global Corporate Communications teams.

Earlier in his career, John was General Counsel at Elan Corporation plc and a senior lawyer at Amgen. John also worked as in the healthcare practice of a national law firm and was a healthcare fraud prosecutor in the U.S. Attorney’s Office and in the Virginia Attorney General’s Office. John earned his undergraduate degree from the University of Virginia and his law degree from the University of Georgia School of Law cum laude. From 2015 through 2022 John served on the Board of Trustees for the American Kidney Fund and chaired the Audit and Compliance Committee.

Aaron has served as Chief Financial Officer since September 2023, bringing over 20 years of experience in financial management, strategic planning and analysis. He joined Mirati in 2022 as senior vice president, financial planning & analysis. In his role, Aaron is responsible for financial planning, management and capital allocation for Mirati. He has extensive experience leading financial teams, strategic planning, executing successful capital raises and managing companies through multiple phases of growth, including commercialization and mergers and acquisitions.

Prior to Mirati, Aaron was Vice President, Finance at Arena Pharmaceuticals, Inc. (acquired by Pfizer), where he oversaw financial planning and analysis, corporate planning and strategic sourcing. Previously, he served as Head of U.S. and Global Commercial Finance at Alexion Pharmaceuticals, Inc. (acquired by Astra Zeneca), where he was responsible for global financial management of Alexion’s Commercial operations. Aaron has also held senior finance roles at Regeneron Pharmaceuticals, Inc.

Aaron received his Bachelor of Science in Finance from Case Western Reserve University.

Mike joined Mirati in 2022 as Chief People Officer (CPO), bringing over 20 years of broad, global people leadership experience working with Boards of Directors and C-level executives to improve organizational capabilities. As CPO, Mike is responsible for guiding and growing Mirati’s people and capabilities, as well as focusing on the company’s talent advancement and growth.

Most recently, Mike served as executive vice president and chief human resources officer at Arena Pharmaceuticals (acquired by Pfizer). Prior to this, he held executive leadership positions at Halozyme Therapeutics, Inc., CareFusion, NuVasive and Life Technologies. Additionally, Mike spent time in leadership roles at Hewlett Packard and EDS (acquired by Hewlett Packard).

Mike currently serves on the board of directors for Orthofix Medical and Silvaco. He received his B.S. in Finance from The Ohio State University.

Alan joined Mirati in 2022 as Chief Medical Officer. In his role, Alan provides leadership and direction over clinical development and operations, regulatory affairs, drug safety and medical strategy. Alan brings nearly 30 years of oncology and drug development experience across industry and academia.

Prior to Mirati, Alan was the president, head of global development, oncology, at Zai Lab. Prior to joining Zai Lab, he was the SVP and global head of late-stage oncology at Genentech, a member of the Roche Group. During his tenure at Genentech/Roche, he led the teams responsible for the global development and regulatory approval of several innovative medicines, most recently Tecentriq^®. Prior to joining Genentech/Roche, Alan served as professor and chief of hematology/oncology at Oregon Health and Science University. Previously, he served on the faculties of the medical schools of Indiana University and Vanderbilt University.

Alan holds a Doctor of Medicine degree from Rush Medical College. He completed his training in internal medicine and a fellowship in medical oncology at Yale-New Haven Medical Center. He has over 300 publications, including articles, reviews, abstracts and book chapters.

Dr. Susan Welsh has served as Senior Vice President, Pharmacovigilance, and Chief Safety Officer, Mirati Therapeutics, since 2021. She is a physician executive with broad and deep experience in global development, medical affairs, regulatory affairs and pharmacovigilance gained during 35 years creating and leading high-functioning global departments. Previously, Susan has held senior roles at Bristol Myers Squibb, Sanofi, CSL Behring, Pfizer, Schering-Plough and GSK.

Throughout her career, Susan has managed robust drug development programs covering the US, Europe and Asia, building globally compliant systems, delivering drug safety plans to meet regulatory expectations worldwide, and defending drug development programs, approvals, labeling and risk management plans at regulatory agency meetings.

Susan is a United Kingdom trained physician and is certified (UK) in general practice and pharmaceutical medicine. She also holds a master’s degree in information management from Washington University in St. Louis, MO, and an MBA from the University of California at Berkeley.

In addition, Susan is an elected Fellow of the Faculty of Pharmaceutical Medicine, Royal Colleges of Physicians UK (FFPM), and a Member of the American College of Physicians. Prior to industry, Susan practiced as a medical doctor for 10 years in the UK, serving for 6 years as an officer in Britain’s Royal Air Force.